Human Characters[]
- Lan Hikari-Curtis Armstrong
- Mayl Sakurai-Laura Baliey
- Dex Oyama-Charlies Adler
- Yui Ayanokoji-Mona Marshall
- Tory Froid-Nika Futterman
- Eugene Chaud-Maurice LaMarche
- Dr. Hikari-Tom Kane
- Masa-Bill Farmer
- Mr. Higsby-Carlos Alazraqui
- Ms. Mari-Kari Wahlgren
- Mrs. Hikari-April Wichelle
- Lord Wily-Jeff Bennett
- Ms. Madd-Cindy Robinson
- Count Zapp-Chris Edgerly
- Mr. Match-Patrick McKenna
- Shukko Kido-Kari Wahlgren
- Dr. Regal-Patrick McKenna
.EXE Units[]
- Mega Man.EXE-Phil LaMarr
- Roll.EXE-Hyden Walch
- GutsMan.EXE-Roger Bumpass
- Glyde.EXE-Mark Hamil
- IceMan.EXE-Billy West
- ProtoMan.EXE-Corey Burton
- Wackoman.EXE-Maurice LaMarch
- SharkMan.EXE-Frank Welker
- CutMan.EXE-Maurice LaMarche
- TorchMan.EXE-Jeff Bennett
- HeatMan.EXE-Jeff Bennett
- StoneMan.EXE-Corey Burton
- WoodsMan.EXE-Billy West
- Aquaman.EXE-Kari Wahlgren
- NumberMan.EXE-Bill Farmer
- Fat CutMan Brother-Jess Harnell
- CutMan Brother w/ hair-Jeff Bennett
- Tallest CutMan Brother-Patrick McKenna
- Taller CutMan Brother-Corey Burton
- Short CutMan Brother-Billy West
- CutMan Elder-Phil LaMarr
- ShadowMan.EXE-Jess Harnell
- BassMan.EXE-Roger Crige Smith
- Mega and Roll's Child-Mona Marshall
- JunkdataMan.EXE-Corey Burton
- AirMan.EXE-David Lodge
- PharaohMan.EXE-Brain-Doyle Murray
Other Types[]
- Rush-Jeff Bennett