| Character | VA |
|---|---|
| Sonic the Hedgehog | Roger Craig Smith |
| Knuckles the Echidna | Travis Willingham |
| Amy Rose | Cindy Robinson |
| Cream the Rabbit | Michelle Ruff |
| Big the Cat | Kyle Hebert |
| Shadow the Hedgehog | Kirk Thornton |
| Rouge the Bat | Karen Strassman |
| Chris Thorndyke | Tara Platt |
| Vector the Crocodile | Keith Silverstein |
| Espio the Chameleon | Troy Baker |
| Miles "Tails" Prower, Charmy Bee | Colleen O'Shaughnessey |
| Cosmo | Stephanie Sheh |
| Linsey Thorndyke | Tiffany Grant |
| Nelson Thorndyke | Dave Wittenberg |
| Chuck Thorndyke | Neil Kaplan |
| Sam Speed | Skip Stellrecht |
| Maria Robotnik | Dorothy Elias Fahn |
| Frances | Philece Sampler |
| Danny | Brianne Siddall |
| Helen | Wendee Lee |
| E-102 Gamma | Vic Mignogna |
| Decoe | Todd Haberkorn |
| Bocoe | Greg Ayres |
| Tikal | Colleen Clinkenbeard |
| Pachacamac | Steven Blum |
| Dr. Eggman | Mike Pollock |
| Scarlet Garcia | Megan Hollingshead |
| Black Narcissus | Sean Schemmel |
| Chris Thorndyke (teenager) | Michael Sinterniklaas |
| Galaxina, Earthia | Veronica Taylor |
- Pollock, Hollingshead, Sinterniklaas, Taylor, and Schemmel's respective voices will mostly remain un-changed from the 4Kids dub.