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Family Guy as an anime is more action, but still funny. I mostly focuses on Peter as an hitman, and Stewie trying to kill Lois. Meg, Chris, and Brian appear sometimes but they are not counted as main characters. Most of the side characters are gone.
Seth MacFarlane - Peter, Brian, Stewie.
Alex Borstein - Lois
Mila Kunis - Meg
Seth Green - Chris